Autoimmune encephalitis: an observational study from South India

Abstract Background Ever since AE was acknowledged as a potentially treatable cause of encephalitis, it has been increasingly recognised worldwide. Data suggests that these disorders are under-recognized, which calls for an increased awareness the varying clinical, laboratory, electrophysiological and radiological presentations different types autoimmune encephalitis. This cross-sectional observational study included all patients diagnosed with AE, who presented to tertiary care centre from June 2016 January 2021. were collected including patient’s demography, electrophysiology studies, management outcomes. Results 31 participants included, 13 anti-NMDA antibody positive, 12 anti-LGI1 2 anti-CASPR2 positive dual status (anti-LGi1 anti-CASPR2), one each anti-GABA-B anti-GAD 65. There marginal male predilection overall seizures being most common symptom (68%) followed by behavioural disturbance (64.5%), impairment consciousness (32.3%). Patients Anti-NMDA encephalitis likely be young females, CSF pleocytosis, more protracted hospital course chances relapse residual disease, while anti-Lgi1 older males shorter, less severe course. Conclusion The present detailed demographic, imaging, laboratory EEG characteristics centre. findings concurred literature demonstrate diverse spectrum clinical manifestations with.